diff --git a/ctxcdb/pebble/pebble.go b/ctxcdb/pebble/pebble.go
index 76793572b7..5df070ac7e 100644
--- a/ctxcdb/pebble/pebble.go
+++ b/ctxcdb/pebble/pebble.go
@@ -263,6 +263,9 @@ func New(file string, cache int, handles int, namespace string, readonly bool) (
 		// debt will be less than 1GB, but with more frequent compactions scheduled.
 		L0CompactionThreshold: 2,
 	}
+	// Disable seek compaction explicitly. Check https://github.com/ethereum/go-ethereum/pull/20130
+	// for more details.
+	opt.Experimental.ReadSamplingMultiplier = -1
 	// These two settings define the conditions under which compaction concurrency
 	// is increased. Specifically, one additional compaction job will be enabled when:
 	// - there is one more overlapping sub-level0;